Yea word Redrum. The only thing that effects sound quality in DAWs is the actual sound quality (bit rate, etc.), and ya of course it's how you use the software and and person using it, just gotta find your thing. I think different programs have different uses. Reason doesn't support VSTs, so if you wanna use all your nice plugins and shit while mixing, then you can't. But Reason has great sound banks so it would be ideal for use as rewired for me. The sequencer on Reason just plain sucks i.m.o though. But if you can make great stuff with Reason then go ahead, i aint complaining.