Im using Ableton, maybe i could help you out with your questions...
I havent tried Reason yet, so I cant compare workflows and etc.
What do you mean the samples sound thin? is it the built in samples/instruments?
Maybe it has something to do with your monitors or headphones?
Ableton tho makes complicated things easier as far as ive been using it.
but changing daw's wouldnt make your sound any better.
I try layering more sounds and a good eq would always make a sound or sample more whole.
hope that helped. if you got more questions ask away, ill try to help as much as i can.
peace!