Yeah, Club Nouveau's - "Why You Treat Me So Bad" used in "I Got 5 On It" and tons of other songs is definitely a song that needs to be retired and Bob James' - "Take Me To The Mardi Gras" as joeburnem said.
Also, J-Lo has ruined Enoch Light Orchestra's - "Hi-Jack", originally sampled by Beatnuts - "Watch Out Now". Well, actually...something like her last 4-5 hits are using samples originally used in a Hip-Hop song...songs that did well I might add.
Mtume's - "Juicy Fruit", used in Biggie's Juicy to name one, Average White Band's - "Person To Person" used by Big Daddy Kane, Puff Daddy, EPMD, Brand Nubian etc are also some songs in need of retiredment.