it isnt just a matter of comfort; its a combination of many factors- money being chief among them. then you think about sounds- what are your sound sources going to be?
if money is not an issue, at all- then by all means- there is no better sampling drum machine/sequencer on the market, and there are many options among them (1000, 2000, 2000xl, 3000, 4000, and 60) and you cant go wrong with either, depending on your needs.
there are so many things to consider. the only way i suggest you go out an buy an mpc at this point in your career is if money is truly not an issue. otherwise, hone your skills on reason and make a little change first, and then venture into the world of hardware.
i speak from an all-hardware perspective for the last three years- until this summer when i finally got tired of spending money. now, i have an excellent pc setup that can compete with my best hardware rig (mpc 2000 and motif rack) and then some. there were certain advantages to having taht setup, but my current pros for outweigh my old ones. there
i recommend you stay put for now.